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Completed projects

Since its formation, RCPAD has successfully designed, delivered and disseminated a number of international collaborative research projects focused on Peripheral Arterial Disease (PAD). Through our global network of clinicians, researchers and healthcare professionals, we have facilitated multicentre studies that generate meaningful real-world evidence to improve patient care and inform future practice. The publications below represent completed RCPAD-supported projects and are available in both online and print formats.

VPAD study: Vessel preparation consensus

Use of Vessel Preparation in Endovascular Peripheral Arterial Disease (PAD) Interventions: A Global Qualitative Analysis

The aim of this study was to establish an international consensus on the definition, aims, and clinical role of vessel preparation in endovascular treatment of peripheral arterial disease (PAD), and to develop practical guidance on its use, barriers to adoption, and priorities for future research.

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The ARISTON Trial 

Atherectomy-assisted endovascular therapy versus open repair for atherosclerotic common femoral artery disease: The multicenter ARISTON study

The aim of this study was to investigate the safety and effectiveness of the endovascular and surgical revascularization techniques for the treatment of consecutive patients with CFA lesions within a real-world registry. Patients will be included with claudication or rest pain due CFA stenosis or occlusion.​

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PARADE STUDY

Elective Surgical Repair of Popliteal Artery Aneurysms with Posterior Approach vs. Endovascular Exclusion: Early and Long Term Outcomes of Multicentre PARADE Study

The aim of this study was compare elective surgical repair of popliteal artery aneurysms (PAAs) via a posterior approach vs. endovascular exclusion, analysing early and five year outcomes in a multicentre retrospective study.

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COSTLY-TLR

Cost Analysis of Target Lesion Revascularisation in Patients With Femoropopliteal In Stent Re-Stenosis or Occlusion: The COSTLY-TLR Study

Funded by Boston Scientific; a Europe-wide project assessing the cost of re-interventions after endovascular therapy in patients with PAD. This is the first multicentre micro-costing exercise in this population of patients. It is supported by RCPAD, FCRE, University of Leicester, and several collaborators across Europe. Results will be published in 2024.

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ENSUPRO

ENdovascular Versus SUrgical Treatment for All-comer Patients With PROsthetic Bypass Graft Occlusion: The Multicentre ENSUPRO Study

Bypass surgery plays a key role in complex lower limb lesions. However, there is a lack of evidence regarding the management of symptomatic prosthetic bypass graft (PBG) occlusion. This study aimed to report outcomes following open, hybrid, or endovascular management of patients presenting with symptomatic PBG occlusion.

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RANDOM-STOP

RANDOMization Screening for Drug coated or Drug Eluting Device Randomised Trials Among Patients Undergoing Endovascular FemorOPopliteal Procedures (RANDOM-STOP study)

The aim was to assess the proportion of patients undergoing endovascular therapy for femoropopliteal arterial disease (F-P) who would be eligible to take part in seven major randomised controlled trials (RCTs) that investigated the efficacy of some of the currently available paclitaxel based (PTX) devices used in this clinical context. Various RCTs have shown a potential clinical benefit from the use of paclitaxel in F-P endovascular therapy. Nonetheless, patients enrolled were highly selected and the generalisability of these findings in pragmatic cohorts is unclear.

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EMOPOP

Different endovascular modalities of treatment for isolated atherosclerotic popliteal artery lesions (EMO-POP) registry

International registry on isolated popliteal artery endovascular treatments. This was a multicentre study across several countries in Europe. EMOPOP represents the largest cohort study to date reporting outcomes after endovascular treatment(s) for isolated popliteal artery disease. The study was completed in less than a year, reporting outcomes relating to the treatment of thousands of patients. Our team pioneered a novel type of statistical analysis in order to report/compare results using several different treatment approaches within the popliteal artery. The full published work is now available on the Journal of Vascular Surgery.

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COBRA study

Covered vs. Bare Metal Stents in the Reconstruction of the Aortic Bifurcation: Early and Midterm Outcomes from the COBRA European Multicentre Registry

Covered vs. Bare Metal Stents in the Reconstruction of the Aortic Bifurcation. This was the 1st major RCPAD study involving several sites across the United Kingdom and Europe. This observational study assessed outcomes following endovascular treatment of complex aorto-iliac occlusive lesion with a variety of techniques and devices. Our network supported data collection, analysis, and dissemination (including statistical analyses to assess treatments’ interactions). Two manuscripts have now been published as a result, one from centres across the United Kingdom, describing a UK-wide experience relating to these endovascular techniques, and one from across Europe. 

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BUBH

Bullying, Undermining, and Harassment) in the vascular healthcare environment.

RCPAD completed an international survey of vascular healthcare professionals (578 participants) to assess the prevalence of BUBH behaviours in the vascular workplace. This is the first international work of this nature. Results are currently in publication and are expected to shape future policy-making in this wider area.

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CONTACT

RCPAD Office

Unit 94 Capital Business Centre, 

22 Carlton Road,

South Croydon, 

Surrey, CR2 0BS

E: office@rcpad.org

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