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ONGOING RESEARCH PROPOSALS

RIVAS SURVEY - Prof. Nicola Troisi

RIVAROXABAN AND VASCULAR SURGERY: A MULTICENTER, INTERNATIONAL SURVEY

Primary Objectives: 

Aim of this study is to investigate the modern relationship between vascular surgeons and rivaroxaban prescription throughout a simple, easy multicenter, international survey to be submitted to vascular surgeons all over the world.

The ARISTON Trial - Grigorios Korosoglou / Konstantinos Donas

ATHRECTOMY-ASSISTED ENDOVASCULAR AND OPEN REPAIR FOR COMMON FEMORAL ARTERY ATHEROSCLEROTIC LESIONS.

(The ARISTON Trial).

Primary Objectives: 

To investigate the safety and effectiveness of the endovascular and surgical revascularization techniques for the treatment of consecutive patients with CFA lesions within a real-world registry. Patients will be included with claudication or rest pain due CFA stenosis or occlusion.

In addition, outcomes including improvement in terms of Rutherford category, target lesion revascularization, will be systematically analyzed in all patients.

The RANDOM-STOP registry - Konstantinos Stavroulakis/ Athanasios Saratzis

Primary Objectives:   

Various randomized control trials (RCTs) have shown a potential clinical benefit, mostly in terms of vessel / lesion patency, using drug coated devices for patients undergoing endovascular femoropopliteal procedures. Nonetheless, these RCTs enrolled highly selected group of patients, in terms of both clinical and imaging criteria. Thus, their results cannot be fully extrapolated to daily practice of most vascular centers treating all-comers. Additionally, these RCTs do not report on the number of screened / excluded patients. This further complicates their applicability to everyday clinical practice, especially with regards to patients with chronic limb threatening ischemia (CLTI). 

This proposed study will retrospectively screen consecutive patients who underwent endovascular procedures between January 2021 and December 2021 (12 months) for femoropopliteal disease and will evaluate the eligibility for randomization for the RCTs of the Food Drug Administration (FDA) approved paclitaxel-coated devices. 

ENSUPRO trial - Dr Grigorios Korosoglou

Primary Objectives: 

To investigate the safety and effectiveness of different endovascular and surgical revascularization techniques for the treatment of patients who present with CLTI due acute or subacute prosthetic bypass graft occlusion.

Based on the time duration between onset of symptoms and presentation limb ischemia is defined as acute in case of patient presentation within 2 weeks after symptom onset and subacute or chronic in case of presentation at 2 weeks and 3 months, respectively after symptom onset.

In addition, outcomes including improvement in terms of Rutherford category, target lesion revascularization, minor and major amputation will be systematically analyzed in all patients.

EMO-POP Registry - Dr Nicola Troisi

Primary Objectives: 

Knee flexion continuously stresses the popliteal artery with high biomechanical forces. As a result, isolated atherosclerotic popliteal artery lesions are quite common in patients with peripheral arterial disease.

During the last years different endovascular modalities of treatment have been proposed to treat these lesions (standard balloon angioplasty, PTA; drug-coated balloon, DCB; atherectomy; stenting). In some papers a combination of more modalities have been reported (directional atherectomy with antirestenotic therapy, DAART).

Hypothesis and specific aims:

Aim of this study is to report the early and long-term outcomes of endovascular treatment of isolated atherosclerotic popliteal artery lesions comparing the different modalities of treatment in the framework of a multicenter retrospective registry.

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